fulltext.study @t Gmail

In vitro, in vivo studies of a new amphiphilic adsorbent for the removal of low-density lipoprotein

Paper ID Volume ID Publish Year Pages File Format Full-Text
12565 800 2003 6 PDF Available
Title
In vitro, in vivo studies of a new amphiphilic adsorbent for the removal of low-density lipoprotein
Abstract

A new amphiphilic adsorbent for the removal of low-density lipoprotein (LDL) was prepared according to the literature (Artif. Cells Blood Subs., Immob. Biotechnol. 30 (4) (2002) 285). The effects of sulfonation and grafting time of cholesterol on the swelling property of adsorbent were studied. When sulfonation and grafting time of cholesterol was 3 and 5 h, respectively, the amphiphilic adsorbent had a high adsorption capacity for LDL without significantly adsorbing high-density lipoprotein. The adsorption capacity of the adsorbent for the removal of LDL, total cholesterol (TC) and TG was 1.916, 2.132, 1.349 mg/ml, respectively. Hyperlipidemia rabbits were developed by feeding with fodder containing high content of cholesterol or yolk, which was then perfused with an optimal amount of amphiphilic adsorbent. After 2 h hemoperfusion, the LDL levels decreased from 3.619±0.354 to 0.724±0.07 mmol/l, which showed that the adsorbent could effectively remove LDL without side effect.

Keywords
Amphiphilic adsorbent; LDL; Hemoperfusion
First Page Preview
In vitro, in vivo studies of a new amphiphilic adsorbent for the removal of low-density lipoprotein
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 13, June 2003, Pages 2189–2194
Authors
, , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering