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A strategy for the development of tissue engineering scaffolds that regulate cell behavior

Paper ID Volume ID Publish Year Pages File Format Full-Text
12574 800 2003 9 PDF Available
Title
A strategy for the development of tissue engineering scaffolds that regulate cell behavior
Abstract

The cellular scaffold represents an extracellular matrix (ECM) in vivo and a culture substratum in vitro, and provides microenvironmental signaling cues based upon the architecture and component for cells. This review article discusses the development of ideal cellular scaffolds for maintaining the activity of functional cells, for regulating cell behavior, and for reconstructing three-dimensional multicellular masses (3-DMMs). Four culture technologies devising the materials of cellular scaffolds developed by author's group are also presented; the preparation of a multicellular spheroid utilizing a thermo-responsive polymer, the preparation of a three-dimensionally reconstructed multicellular mass (3-DRMM) with a medium circulating system utilizing cotton-gauze, a concept for organ engineering that can remodel an organ into a reconstructed organ by a continuous three-step perfusion to change the cellular scaffold, and a concept for cellomics study to culture cells on a substratum made of tissue/organ sections for histopathology (TOSHI-substratum) that conserve the microarchitecture and component of the original tissue in vivo. The former two tissue engineering technologies still lacked the method to design 3-DMMs with hierarchical tissue architectures based on cell lineages. To overcome this task, the latter two technologies that can convert tissue architecture in vivo into the three-dimensional culture mode in vitro were innovated.

Keywords
Scaffold; Tissue engineering; Multicellular spheroid; TOSHI-substratum; Cellomics
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A strategy for the development of tissue engineering scaffolds that regulate cell behavior
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 13, June 2003, Pages 2267–2275
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us