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Transplantation of cultured bone cells using combinations of scaffolds and culture techniques

Paper ID Volume ID Publish Year Pages File Format Full-Text
12575 800 2003 10 PDF Available
Title
Transplantation of cultured bone cells using combinations of scaffolds and culture techniques
Abstract

The transplantation of cultured bone cells is expected to become a candidate for bone regeneration therapy. For the clinical application of this therapy, there remain several problems to be overcome, for example, the improvements of scaffolds and culture techniques. In this review article, two kinds of porous ceramics, a novel sintered porous hydroxyapatite and a porous beta-tricalcium phosphate (TCP), as well as a collagen-phosphosphoryn sponge are introduced as new scaffolds for bone regeneration. The former two ceramic scaffolds proved to be applicable for bone regeneration therapy. The collagen-phosphophoryn sponge proved to have bone formation ability in vivo. Moreover, for the application of this therapy to the regeneration of large bone defects, we improved the culture method by applying a low-pressure system and a perfusion system. Both culture systems accelerated the formation of bone in vivo in this transplantation model. Combinations of the scaffolds and culture techniques might be considered when designing therapeutic strategies.

Keywords
Bone; Regeneration; Hydroxyapatite; Beta-TCP; Low-pressure; Perfusion culture
First Page Preview
Transplantation of cultured bone cells using combinations of scaffolds and culture techniques
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 13, June 2003, Pages 2277–2286
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering