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Glial cell and fibroblast cytotoxicity study on plasma-deposited diamond-like carbon coatings

Paper ID Volume ID Publish Year Pages File Format Full-Text
12596 803 2003 7 PDF Available
Title
Glial cell and fibroblast cytotoxicity study on plasma-deposited diamond-like carbon coatings
Abstract

Diamond-like carbon films have been evaluated as coatings to improve biocompatibility of orthopedic and cardiovascular implants. This study initiates a series of investigations that will evaluate diamond-like carbon (DLC) as a coating for improved biocompatibility in chronic neuroprosthetic implants. Studies in this report assess the cytotoxicity and cell adhesion behavior of DLC coatings exposed to glial and fibroblast cell lines in vitro. It can be concluded from these studies that DLC coatings do not adversely affect 3T3 fibroblast and T98-G glial cell function in vitro. We also successfully rendered DLC coatings non-adhesive (no significant fibroblast or glial cell adhesion) with surface immobilized dextran using methods developed for other biomaterials and applications. Future work will further develop DLC coatings on prototype microelectrode devices for chronic neural implant applications.

Keywords
Diamond-like carbon films; Surface modification; Neural prosthetics; Immobilized dextran; Cell-resistant surface
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Glial cell and fibroblast cytotoxicity study on plasma-deposited diamond-like carbon coatings
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 28, December 2003, Pages 5083–5089
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us