Frictional properties of poly(MPC-co-BMA) phospholipid polymer for catheter applications
A fundamental understanding of surface properties of the biomaterials at a nanometer scale should be generated in order to understand cellular responses of the tissue to biomaterials thereby minimizing or eliminating tissue trauma at a macrometer scale. In this study poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) ([poly(MPC-co-BMA]) was evaluated as a potential coating material for vascular applications to provide smooth catheterization using atomic force microscopy (AFM) techniques.A uniform coating of [poly(MPC-co-BMA] equivalent to a thickness of 2.5 μm on a polyurethane (PU) catheter material was provided using dip casting technique. Using a contact mode AFM, no significant difference in surface roughness (Ra) and frictional force (f) between uncoated (Ra=10.2±1.9 nm, f=0.907±0.02) and coated (Ra=11.7±1.8 nm, f=0.930±0.06) surfaces was observed under dry conditions. However, under wet conditions the Ra of the coated surface (3.4±1.0 nm) was significantly lower than uncoated PU surface (9.0±1.8 nm). The coating on PU substrate offered the least frictional resistance (f=0.004±0.001) illustrating enhanced boundary lubrication capability due to hydration of phosphorylcholine polymer as compared to a significantly higher f for uncoated PU (0.017±0.007) surfaces. These tribological and chemical characteristics of the [poly(MPC-co-BMA)] coating could increase the overall efficacy of PU for clinical applications.
Journal: Biomaterials - Volume 24, Issue 28, December 2003, Pages 5121–5129