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Calcium phosphate formation and ion dissolution rates in silica gel-PDLLA composites

Paper ID Volume ID Publish Year Pages File Format Full-Text
12606 803 2003 10 PDF Available
Title
Calcium phosphate formation and ion dissolution rates in silica gel-PDLLA composites
Abstract

Sol–gel derived silicas are potential biomaterials both for tissue regeneration and drug delivery applications. In this study, both SiO2 and calcium and phosphate-containing SiO2 (CaPSiO2) are combined with poly-(dl-lactide) to form a composite. The main properties studied are the ion release rates of biologically important ions (soluble SiO2 and Ca2+) and the formation of bone mineral-like calcium phosphate (CaP) on the composite surface. These properties are studied by varying the quality, content and granule size of silica gel in the composite, and porosity of the polymer. The results indicate that release rates of SiO2 and Ca2+ depend mostly on the formed CaP layer, but in some extent also on the granule size of silicas and polymer porosity. The formation of the bone mineral-like CaP is suggested to be induced by a thin SiO− layer on the composite surface. However, due to absence of active SiO2 or CaPSiO2 granules on the outermost surface, the suitable nanoscale dimensions do not contribute the nucleation and growth and an extra source for calcium is needed instead. The result show also that all composites with varying amount of CaPSiO2 (10–60 wt%) formed bone mineral-like CaP on their surfaces, which provides possibilities to optimise the mechanical properties of composites.

Keywords
SiO2 gels; Composite; Ion release; Calcium phosphate formation
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Calcium phosphate formation and ion dissolution rates in silica gel-PDLLA composites
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 28, December 2003, Pages 5173–5182
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us