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Degradation of phospholipid polymer hydrogel by hydrogen peroxide aiming at insulin release device

Paper ID Volume ID Publish Year Pages File Format Full-Text
12607 803 2003 8 PDF Available
Title
Degradation of phospholipid polymer hydrogel by hydrogen peroxide aiming at insulin release device
Abstract

The purpose of this study is to ascertain the applicable possibility of H2O2 degradable hydrogel for fabrication of insulin release system synchronized with the change in the glucose concentration in the medium. The hydrogel was prepared by using 2-methacryloyloxyethyl phosphorylcholine (MPC) and crosslinker. The favorable characteristic of the hydrogel was H2O2 concentration responsive degradation. The H2O2 was utilized and produced by enzymatic reaction between glucose oxidase and glucose. Poly(MPC) (PMPC) was easily degraded in H2O2 aqueous solution, and the PMPC hydrogel was also degraded in H2O2 aqueous solution. The degradation mechanism was considered to be main chain scission of PMPC. The degradation profile was evaluated by using weight swelling ratio and volume swelling ratio. The weight swelling ratio of PMPC hydrogel firstly increased due to the reduction of crosslink density, then the ratio decreased to zero (complete degradation). The degradation profile was proportional to the H2O2 concentration. Furthermore, volume swelling ratio also increased, and complex elastic modulus decreased with degradation in H2O2 aqueous solution. These results indicated that the hydrogel was degraded by hydroxy and/or hydroperoxy radicals which was produced by H2O2, the crosslink density and mechanical property decreased. The release profile from the hydrogel was estimated by using lipid microsphere (LM) as an insulin model. The LM was released with the degradation of PMPC hydrogel. Taking these results into account, the PMPC hydrogel was available for H2O2 degradable hydrogel for synchronization with glucose concentration by using enzymatic reaction.

Keywords
Phospholipid polymer; Hydrogel; Insulin release device; Glucose-responsive
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Degradation of phospholipid polymer hydrogel by hydrogen peroxide aiming at insulin release device
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 28, December 2003, Pages 5183–5190
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us