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In vitro cytotoxicity of nitric oxide-releasing sol–gel derived materials

Paper ID Volume ID Publish Year Pages File Format Full-Text
12619 805 2005 11 PDF Available
Title
In vitro cytotoxicity of nitric oxide-releasing sol–gel derived materials
Abstract

The cytotoxicity of bare and PU-coated nitric oxide (NO)-releasing sol–gel derived materials (sol–gels) was investigated using L929 mouse fibroblasts in both direct and indirect contact models to differentiate between the biological impact of the sol–gel matrix and NO release. The flux of NO was varied up to 150 pmol cm−2 s−1 using N-(6-aminohexyl)-aminopropyltrimethoxysilane (balance iso-butyltrimethoxysilane) diazeniumdiolate (NO donor)-modified sol–gels. The addition of a polyurethane (PU) outer membrane greatly improved the stability of the sol–gel matrix without significantly suppressing the NO flux. Direct contact studies demonstrated a cytotoxic effect that was dependent on the aminosilane content of the sol–gel. The use of the thin PU overcoat eliminated this effect. A direct cytotoxicity dependence of NO release for L929 fibroblasts was discovered from indirect contact studies, where 24 h exposure to NO fluxes in excess of 50 pmol cm−2 s−1 was cytotoxic.

Keywords
Nitric oxide; Sol–gel; Controlled release; Fibroblasts; Biocompatibility
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In vitro cytotoxicity of nitric oxide-releasing sol–gel derived materials
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 21, July 2005, Pages 4405–4415
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us