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Silicone elastomers for reduced protein adsorption

Paper ID Volume ID Publish Year Pages File Format Full-Text
12635 806 2004 10 PDF Available
Title
Silicone elastomers for reduced protein adsorption
Abstract

Monofunctional poly(ethylene oxide) polymers of molecular weight (MW) 350, 750, and 2000, respectively, were modified with Si(OEt)3 groups. These polymers underwent classic condensation cure with hydroxy-terminated silicone polymers and Si(OEt)4 to give composites with poly(ethylene oxide) (PEO) rich surfaces under aqueous conditions, as shown by contact angle and XPS data. The hydrophobicity of the surfaces was considerably higher in air. The greatest PEO concentration was observed with relatively short chain polymers of MW 350. Silicone polymers bearing short chain PEO chains were also observed to be the most protein rejecting from either buffer (fibrinogen) (90%) or plasma (85%). The silicone/TES-MPEO formulation offers the advantage of a one step/one shot polymerization process that gives materials with a high protein rejection ability than can be cast as films, or molded into complex shapes. Covalently linked PEO films of a variety of chain lengths and total surface coverage can be readily accommodated.

Keywords
Poly(dimethylsiloxane) elastomer; Poly(ethylene oxide) surface modification; Protein adsorption
First Page Preview
Silicone elastomers for reduced protein adsorption
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 12, May 2004, Pages 2273–2282
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering