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Preparation and characteristics of hybrid scaffolds composed of β-chitin and collagen

Paper ID Volume ID Publish Year Pages File Format Full-Text
12639 806 2004 9 PDF Available
Title
Preparation and characteristics of hybrid scaffolds composed of β-chitin and collagen
Abstract

Hybrid scaffolds composed of β-chitin and collagen were prepared by combining salt-leaching and freeze-drying methods. The chitin scaffold used as a framework was easily formed into desired shapes with a uniformly distributed and interconnected pore structure with average pore size of 260–330 μm. The mechanical strength and the rate of biodegradation increased with the porosity, which could be modulated by the salt concentration. In addition, atelocollagen solution was introduced into the macropores of the chitin scaffold to improve cell attachment. Web-like collagen fibers fabricated between pores of chitin were produced by a 0.1 wt% collagen solution, whereas a 0.5 wt% collagen solution only coated the surface of the chitin scaffold. After 3 days of culture, fibroblasts cultured in collagen-coated scaffolds were attached at the place where the collagen was fabricated, whereas cells did not attach and aggregate on the scaffold of chitin alone. After 14 days, the fibroblasts showed a good affinity to and proliferation on all collagen-coated chitins.

Keywords
Chitin; Collagen; Scaffold; Wound dressing
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Preparation and characteristics of hybrid scaffolds composed of β-chitin and collagen
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 12, May 2004, Pages 2309–2317
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us