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Biocompatibility of poly(ε-caprolactone)/poly(ethylene glycol) diblock copolymers with nanophase separation

Paper ID Volume ID Publish Year Pages File Format Full-Text
12673 809 2004 9 PDF Available
Title
Biocompatibility of poly(ε-caprolactone)/poly(ethylene glycol) diblock copolymers with nanophase separation
Abstract

In this study, we prepared diblock copolymers of poly(ε-caprolactone) (PCL) and poly(ethylene glycol) (PEG) by aluminum alkoxide catalysts. The biological responses to the spin cast surface of different PCL/PEG diblock copolymers were investigated in vitro. Our results showed that surface hydrophilicity improved with the increased PEG segments in diblock copolymers and that bacteria adhesion was inhibited by increased PEG contents. PCL–PEG 23:77 showed nanotopography on the surface. The number of adhered endothelial cells, platelets and monocytes on diblock copolymer surfaces was inhibited in PCL–PEG 77:23 and enhanced in PCL–PEG 23:77. Nevertheless, the platelet and monocyte activation on PCL–PEG 23:77 was reduced. PCL–PEG 23:77 had better cellular response as well as lower degree of platelet and monocyte activation. The current study was the first one to demonstrate that surface nanotopography could influence not only cell adhesion and growth but also platelet and monocyte activation.

Keywords
PCL/PEG diblock copolymer; Microphase separation; Nanotopography; Cell response; Inflammation; Platelet activation
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Biocompatibility of poly(ε-caprolactone)/poly(ethylene glycol) diblock copolymers with nanophase separation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 25, November 2004, Pages 5593–5601
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us