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A study of properties of “micelle-enhanced” polyelectrolyte capsules: Structure, encapsulation and in vitro release

Paper ID Volume ID Publish Year Pages File Format Full-Text
1269 80 2009 10 PDF Available
Title
A study of properties of “micelle-enhanced” polyelectrolyte capsules: Structure, encapsulation and in vitro release
Abstract

“Micelle-enhanced” polyelectrolyte capsules were fabricated via a layer-by-layer technique, templated on hybrid calcium carbonate particles with built-in polymeric micelles based on polystyrene-b-poly(acrylic acid). Due to the presence of a large number of negatively charged micelles inside the polyelectrolyte capsule, which were liberated from templates, the capsule wall was reconstructed and had properties different to those of conventional polyelectrolyte capsules. This type of capsule could selectively entrap positively charged water-soluble substances. The encapsulation efficiency of positively charged substances was dependent on their molecular weight or size. For some positively charged compounds, such as rhodamine B and lysozyme, the concentration in the capsules was orders of magnitude higher than that in the incubation solution. In addition, in vitro release study suggested that the encapsulated compounds could be released through a sustained manner to a certain degree. All these results point to the fact that these capsules might be used as novel delivery systems for some water-soluble compounds.

Keywords
Functionalized templates; Self-assembly; Polyelectrolyte capsules; Water-soluble substances; Induced deposition
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A study of properties of “micelle-enhanced” polyelectrolyte capsules: Structure, encapsulation and in vitro release
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 6, July 2009, Pages 2122–2131
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us