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Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
12697 810 2005 7 PDF Available
Title
Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles
Abstract

Cellular localization of nanoparticles (Np) represents an important target in the understanding of their distribution after endovenous injection. The need of suitable devices and methodologies capable to detect Np in tissues or in cellular districts can be satisfied by Np which have to be easily recognizable by simple methods. Conjugations of poly(D,L-lactide-co-glycolide) with fluorescein and biotin allow fluorescent and immuno-histochemically active Np to be obtained. The fluorescein Np are detectable using fluorescent microscopy whereas biotin Np can be detected by optical microscopy after streptavidin–biotin–peroxidase complexation. In vivo experiments confirm the ability of these particles to be easily detected in the brain parenchyma or in the liver cell population according to the infusion pathway.

Keywords
Nanoparticles; Fluorescein–PLGA conjugate; Biotin-PLGA conjugate; In vivo localization
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Conjugated poly(D,L-lactide-co-glycolide) for the preparation of in vivo detectable nanoparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 19, July 2005, Pages 4189–4195
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us