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Intercalation behavior and tensile strength of DNA–lipid films for the dental application

Paper ID Volume ID Publish Year Pages File Format Full-Text
12705 813 2004 7 PDF Available
Title
Intercalation behavior and tensile strength of DNA–lipid films for the dental application
Abstract

In this study, we prepared DNA–lipid films and examined their intercalation behavior and tensile strength as an indicator for usefulness as a dental material. The lipids were synthesized from the reaction of glycine, l-alanine, or l-glutamic acid with n-alkyl alcohol in the presence of p-toluenesulfonic acid. The self-standing, water-insoluble DNA–lipid films were prepared by casting the DNA–lipid complex from chloroform/ethanol solution. The DNA–lipid films formed intercalation complexes with ethidium bromide. This indicates that DNA–lipid films maintain a double helical structure. The tensile strengths of DNA films were 0.8–2.4 MPa and were compatible with a commercially available material (Membrane) for guided tissue regeneration in dental use. We conclude that DNA–lipid films have potential for use as a material for the surface treatment of implanted materials or as a bone-guiding scaffold for dental application.

Keywords
DNA; Lipid; Scaffold; Tensile strength
First Page Preview
Intercalation behavior and tensile strength of DNA–lipid films for the dental application
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 24, November 2004, Pages 5491–5497
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering