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Improved hemocompatibility of poly(ethylene terephthalate) modified with various thiol-containing groups

Paper ID Volume ID Publish Year Pages File Format Full-Text
12727 814 2005 7 PDF Available
Title
Improved hemocompatibility of poly(ethylene terephthalate) modified with various thiol-containing groups
Abstract

Thiol groups were attached to polyethylene terephthalate (PET) to promote the transfer of a known platelet inhibitor, nitric oxide (NO), from nitrosated thiols naturally found in the body to PET, followed by the release of NO from PET to prevent platelet adhesion. In order to immobilize the most thiols on the modified polymer, the processing parameters used to attach the following three thiol containing groups were assessed: l-cysteine, 2-iminothiolane, and a cysteine polypeptide. When comparing the immobilized concentrations of thiol groups from each of the optimized processes the amount of immobilized thiol groups increased in order with the following groups: cysteine polypeptide <2-iminothiolane

Keywords
L-cysteine; 2-Iminothiolane; Cysteine polypeptide; Platelets; Poly(ethylene terephthalate) (PET)
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Improved hemocompatibility of poly(ethylene terephthalate) modified with various thiol-containing groups
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 17, June 2005, Pages 3479–3485
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
Online Support
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