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Stimulation of bone formation by zoledronic acid in particle-induced osteolysis ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
12753 814 2005 7 PDF Available
Title
Stimulation of bone formation by zoledronic acid in particle-induced osteolysis ☆
Abstract

We investigated the effect of a single subcutaneous dose of zoledronic acid on particle-induced osteolysis and observed excessive regional new bone formation.We utilized the murine calvarial osteolysis model and polyethylene particles in C57BL/J6 mice. Twenty-eight mice were used, seven per group. Specimens were stained with Giemsa dye. The osteoid tissue area was determined. Bone thickness was measured as an indicator of bone growth.Net bone growth was significantly increased in animals with zoledronic acid treatment: 0.02 mm2±0.03 mm2 in animals with particle implantation only (group 2), 0.25 mm2±0.08 mm2 with particle implantation and zoledronic acid treatment directly after surgery (group 3; p=0.0018p=0.0018), and 0.21 mm2±0.11 mm2 with particle implantation and zoledronic acid treatment on the fourth postoperative day (group 4; p=0.0042p=0.0042). The mean bone thickness was 0.2 mm±0.04 mm (range 0.17 mm–0.31 mm) in group 1 (sham controls) and 0.16 mm±0.02 mm (range 0.14 mm–0.19 mm) in group 2, 0.31 mm±0.04 mm (range 0.28 mm–0.39 mm) in group 3, and 0.29 mm±0.02 mm (range 0.28 mm–0.34 mm) in group 4. Student's t  -test revealed a statistically significant difference between groups 2 and 3 (p=0.00042p=0.00042), and groups 2 and 4 (p=0.0019p=0.0019).In conclusion, our observational study suggests that zoledronic acid may stimulate bone apposition locally in the process of particle-induced osteolysis.

Keywords
Net bone growth; Wear debris; Polyethylene particles; Histomorphometry; Zoledronic acid
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Stimulation of bone formation by zoledronic acid in particle-induced osteolysis ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 17, June 2005, Pages 3719–3725
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us