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Chondrocyte behaviors on poly-l-lactic acid (PLLA) membranes containing hydroxyl, amide or carboxyl groups ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
12768 816 2003 6 PDF Available
Title
Chondrocyte behaviors on poly-l-lactic acid (PLLA) membranes containing hydroxyl, amide or carboxyl groups ☆
Abstract

Hydrophilic groups, i.e. hydroxyl (–OH), carboxyl (–COOH) or amide (–CONH2) were introduced onto the poly-l-lactic acid (PLLA) membrane surfaces via the photo-induced grafting copolymerization of the corresponding monomers, i.e. hydroxyethyl methacrylate, methacrylic acid or acrylamide, respectively. Chondrocyte culture was used to study the correlation between the cell behaviors and the hydrophilic functional groups. The results showed that the cytocompatibility of the PLLA membranes with hydroxyl or amide groups on the surface was greatly improved compared to that of the original PLLA membrane. However, the PLLA membrane with carboxyl groups on the surface had even worse cytocompatibility though possessed a similar hydrophilicity.

Keywords
Poly-l-lactic acid (PLLA); Hydrophilicity; Cytocompatibility; Surface modification; Chondrocyte
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Chondrocyte behaviors on poly-l-lactic acid (PLLA) membranes containing hydroxyl, amide or carboxyl groups ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 21, September 2003, Pages 3725–3730
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us