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The fabrication and biochemical evaluation of alumina reinforced calcium phosphate porous implants

Paper ID Volume ID Publish Year Pages File Format Full-Text
12769 816 2003 9 PDF Available
Title
The fabrication and biochemical evaluation of alumina reinforced calcium phosphate porous implants
Abstract

Alumina reinforced calcium phosphate porous implants were manufactured to improve the mechanical strength while maintaining the bioactivity of calcium phosphate ceramics. The alumina porous bodies, which provided the mechanical strength, were fabricated by a polyurethane sponge method and multiple coating techniques resulted in the porous bodies with a 90–75% porosity and a compressive strength of up to ∼6 MPa. The coating of hydroxyapatite (HAp) or tricalcium phosphate (β-TCP) was performed by dipping the alumina porous bodies into calcium phosphate ceramic slurries and sintering the specimens. The fairly strong bonding between the HAp or TCP coating layer and the alumina substrate was obtained by repeating the coating and sintering processes. The biochemical evaluations of the porous implants were conducted by in vitro and in vivo tests. For in vitro test, the implants were immersed in Ringer’s solution and the release of Ca and P ions were detected and compared with those of calcium phosphate powders. For in vivo test, the porous bodies were implanted into mixed breed dogs and bone mineral density measurements and histological studies were conducted. The alumina reinforced HAp porous implants had a higher strength than the HAp porous implants and exhibited a similar bioactivity and osteoconduction property to the HAp porous implants.

Keywords
Calcium phosphate; Alumina; Porous implant; Bone mineral density
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The fabrication and biochemical evaluation of alumina reinforced calcium phosphate porous implants
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 21, September 2003, Pages 3731–3739
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us