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Cell adhesion on gaseous plasma modified poly-(l-lactide) surface under shear stress field

Paper ID Volume ID Publish Year Pages File Format Full-Text
12772 816 2003 8 PDF Available
Title
Cell adhesion on gaseous plasma modified poly-(l-lactide) surface under shear stress field
Abstract

A series of gases were used for plasma treatment of poly-(l-lactide) (PLLA) under various conditions such as atmosphere, electric power, pressure and time. The NH3 was preferably selected for modifying the surface of PLLA because it can obtain appropriate hydrophilicity and surface energy with high polar component compared to other gases. Subsequently, cells were seeded onto NH3 modified surface and exposed to 29.5 N/m2 of shear stress field by means of a parallel plate flow chamber in order to get good insight into the influence of N-containing incorporation on cell retention, cell morphology, and cell shape factor. The results showed that cell retention on the modified PLLA was much higher than that on the unmodified one. The NH3 plasma modified PLLA with high cell affinity and resistance to shear stress was gained. Surface hydrophilicity, surface energy with high polar component and N-containing groups may play an important role in enhancing cell resistance to shear stress. It revealed that the parallel plate flow chamber is an effective device for evaluating the effects of surface modification on the cell affinity of a material.

Keywords
Poly-(l-lactide); Plasma treatment; Surface modification; Shear stress; Tissue engineering
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Cell adhesion on gaseous plasma modified poly-(l-lactide) surface under shear stress field
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 21, September 2003, Pages 3757–3764
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us