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Radiation synthesis of interpolymer polyelectrolyte complex and its application as a carrier for colon-specific drug delivery system

Paper ID Volume ID Publish Year Pages File Format Full-Text
12841 818 2005 7 PDF Available
Title
Radiation synthesis of interpolymer polyelectrolyte complex and its application as a carrier for colon-specific drug delivery system
Abstract

Novel pH-sensitive interpolymer polyelectrolyte complex was synthesized by gamma radiation-induced copolymerization of acrylic acid (AAc) and dimethyl aminoethyl methacrylate (DMAEMA). pH-dependent swelling showed different phase transitions depending on the copolymer composition and also showed the interpolymer polyelectrolyte complex formation at pH values ranged from pH 3 to pH 4. FT-IR and TGA was employed to study the complex formation. The influence of copolymer composition and pH value of the surrounding medium on the type of water diffusion in the glassy polymer was discussed. The ability of the prepared copolymer to be used as drug carrier for colon-specific drug delivery system was estimated using ketoprofen as a model drug.

Keywords
Dimethyl aminoethyl methacrylate; PH-sensitive; Interpolymer complex; Colon-specific; Drug release
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Radiation synthesis of interpolymer polyelectrolyte complex and its application as a carrier for colon-specific drug delivery system
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 26, Issue 15, May 2005, Pages 2733–2739
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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