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Towards a fully-synthetic substitute of alginate: development of a new process using thermal gelation and chemical cross-linking

Paper ID Volume ID Publish Year Pages File Format Full-Text
12849 819 2004 10 PDF Available
Title
Towards a fully-synthetic substitute of alginate: development of a new process using thermal gelation and chemical cross-linking
Abstract

We have previously described a gelation process based on the occurrence of both physical and a chemical mechanisms (‘tandem process’), in which a telechelic linear poly(propylene glycol)-bl-poly(ethylene glycol)-bl-poly(propylene glycol) is first thermally gelled and subsequently covalently cross-linked by the reaction of polymer end groups at the termini of the copolymer. The quick kinetics of the reverse thermal gelation and the harmless character of the Michael-type addition between two sets of terminal groups, acrylates on one set and thiols on the other, allows irreversibly cross-linked hydrogels to be obtained in a rapid and biocompatible fashion, even when gelation was conducted in direct contact with cells. This allows in principle for an application of the tandem process in cell encapsulation. In the present work, we have optimized the macromolecular architecture and functionality of the precursors for allowing the use of the tandem process in encapsulation devices designed for calcium alginate. The mechanical, diffusional and biocompatibility properties of these materials were characterized; the comparison of mass transport properties of the tandem gels with those of calcium alginate suggests a similar or even better immunoisolation effect.

Keywords
Thermosensitive polymers; Tetronics; Michael-type addition; Cell encapsulation
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Towards a fully-synthetic substitute of alginate: development of a new process using thermal gelation and chemical cross-linking
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 21, September 2004, Pages 5115–5124
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
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