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Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
12855 819 2004 10 PDF Available
Title
Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering
Abstract

A novel biodegradable nanocomposite porous scaffold comprising a β-tricalcium phosphate (β-TCP) matrix and hydroxyl apatite (HA) nanofibers was developed and studied for load-bearing bone tissue engineering. HA nanofibers were prepared with a biomimetic precipitation method. The composite scaffolds were fabricated by a method combining the gel casting and polymer sponge techniques. The role of HA nanofibers in enhancing the mechanical properties of the scaffold was investigated. Compression tests were performed to measure the compressive strength, modulus and toughness of the porous scaffolds. The identification and morphology of HA nanofibers were determined by X-ray diffraction and transmission electron microscopy, respectively. Scanning electron microscopy was used to examine the morphology of porous scaffolds and fracture surfaces to reveal the dominant toughening mechanisms. The results showed that the mechanical property of the scaffold was significantly enhanced by the inclusion of HA nanofibers. The porous composite scaffold attained a compressive strength of 9.8±0.3 MPa, comparable to the high-end value (2–10 MPa) of cancellous bone. The toughness of the scaffold increased from 1.00±0.04 to 1.72±0.02 kN/m, as the concentration of HA nanofibers increased from 0 to 5 wt %.

Keywords
Porous scaffolds; Nanofibers; Bone; Tissue engineering
First Page Preview
Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 21, September 2004, Pages 5171–5180
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering