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Release profile of antimicrobial agents from α-tricalcium phosphate cement

Paper ID Volume ID Publish Year Pages File Format Full-Text
12862 820 2001 5 PDF Available
Title
Release profile of antimicrobial agents from α-tricalcium phosphate cement
Abstract

A new method for treating carious dentine with α-tricalcium phosphate (α-TCP) dental cement containing antimicrobial agents has been recently introduced. However, the release behavior of antimicrobial agents from this cement has not yet been clarified. The aim of this study is therefore to examine the release profile of the antimicrobial agents from the α-TCP cement. Three kinds of antimicrobial agents (metronidazole, cefaclor and ciprofloxacin) were added to two commercially available α-TCP cements (new apatite liner type I and type II). The set cements were then immersed in water at 37°C and the released antimicrobial agents and Ca ion were determined at regular intervals for three months. In addition, scanning electron microscopic observations were conducted before and after immersion for three months. The release profile of the cements containing antimicrobial agents varied depending on the types of antimicrobial agents. The incorporation of antimicrobial agents affected the setting reaction of the cements. The release behavior of the drugs also varied depending on the types of the cements. The differences in the release profile between type I and type II cements reflected the structures and compositions of their matrices.

Keywords
Release profile; Metronidazole; Cefaclor; Ciprofloxacin; α-Tricalcium phosphate cement
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Release profile of antimicrobial agents from α-tricalcium phosphate cement
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 20, 15 October 2001, Pages 2713–2717
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us