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Synthesis, characterization, and blood compatibility of polyamidoamines copolymers

Paper ID Volume ID Publish Year Pages File Format Full-Text
12877 821 2003 9 PDF Available
Title
Synthesis, characterization, and blood compatibility of polyamidoamines copolymers
Abstract

This work reports the development of new non-thrombogenic polymers based on the linear polymers of polyamidoamines (PAAs), having heparin binding ability, obtained by polyaddition of secondary amines to N,N′-methylene bis-acrylamide. PAAs could not be used directly in the making of blood-contacting materials due to their poor mechanical strength. In order to overcome this lacuna, copolymers of amidoamine with methylmethacrylate (MMA) were prepared. Characterization studies indicated that the PAAs have been suitably incorporated into the MMA matrix. The relative hydrophilic nature of the synthesized copolymers was established from the measurement of water contact angle. The heparinized copolymers showed significant improvement in non-thrombogenic characteristics.

Keywords
Hemocompatibility; Hemolysis; Heparin; Polyamidoamine; Blood compatible polymers
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Synthesis, characterization, and blood compatibility of polyamidoamines copolymers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 18, August 2003, Pages 2985–2993
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us