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Characterisation of bioactive and resorbable polylactide/Bioglass® composites by FTIR spectroscopic imaging

Paper ID Volume ID Publish Year Pages File Format Full-Text
12898 822 2004 8 PDF Available
Title
Characterisation of bioactive and resorbable polylactide/Bioglass® composites by FTIR spectroscopic imaging
Abstract

Formation, size and distribution of hydroxyapatite domains in resorbable composites made of poly(dl-lactide) foams and Bioglass® particles after exposure to a solution of phosphate-buffer saline (PBS) for different periods of time have been analysed with FTIR imaging using the micro-ATR-IR approach. The spectral information of 4096 spectra measured simultaneously with the IR microscope equipped with a focal plane infrared array detector allowed us to obtain chemical images showing the distribution of Bioglass® particles in the composites. FTIR imaging in micro-ATR mode allowed to obtain images with enhanced spatial resolution. A random distribution of hydroxyapatite domains with average size of ca. 10 μm on the surface of the composites was found after exposure to PBS for 14 and 28 days. The further growth of the hydroxyapatite domains after exposure to PBS for 63 days was detected. The spectroscopic imaging method introduced here promises to become a powerful method for characterisation of resorbable polymer composites containing bioactive inorganic phases developed for bone tissue engineering scaffolds. The accurate detection of hydroxyapatite domains and the imaging of their location in the scaffold structure is required to provide an assessment of the composites bioactivity.

Keywords
FT-IR; Bioactivity; Scaffold; Bioactive glass; Polylactid acid; ATR-IR; Image analysis
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Characterisation of bioactive and resorbable polylactide/Bioglass® composites by FTIR spectroscopic imaging
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 18, August 2004, Pages 3931–3938
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us