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Bioactivation of titanium surfaces using coatings of TiO2 nanotubes rapidly pre-loaded with synthetic hydroxyapatite

Paper ID Volume ID Publish Year Pages File Format Full-Text
1290 80 2009 9 PDF Available
Title
Bioactivation of titanium surfaces using coatings of TiO2 nanotubes rapidly pre-loaded with synthetic hydroxyapatite
Abstract

Apatite depositions from simulated body fluid (SBF) have been widely used for the in vitro assessment of the bioactivity of bone- and dental-implant materials. In previous work, we reported that titanium-based implant materials can be coated with an anodic TiO2 nanotube layer which can significantly stimulate apatite formation. In the present work, we demonstrate that the tubular nature of such coatings makes them highly suitable for the application of a treatment called “alternative immersion method (AIM)”, which preloads the coatings with synthetic hydroxyapatite. This treatment is indeed found to additionally promote natural apatite formation significantly. To study the AIM effect, layers of nanotubes with various diameters and crystal structures (amorphous, anatase/rutile) were produced, AIM-treated, and the formation of apatite in SBF10 (10 mmol 1−1 HCO3−) was evaluated. The results show a drastic enhancement of apatite deposition rates (in some cases >20-fold acceleration) for AIM-treated TiO2 nanotube layers in comparison with non-treated TiO2 surfaces.

Keywords
TiO2 nanotubes; Hydroxyapatite; Simulated body fluid; Anodization; Alternative immersion method
First Page Preview
Bioactivation of titanium surfaces using coatings of TiO2 nanotubes rapidly pre-loaded with synthetic hydroxyapatite
Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 6, July 2009, Pages 2322–2330
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering