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Mutagenic potentials of dental cements as detected by the Salmonella/microsome test

Paper ID Volume ID Publish Year Pages File Format Full-Text
12907 822 2004 9 PDF Available
Title
Mutagenic potentials of dental cements as detected by the Salmonella/microsome test
Abstract

The potential mutagenicity of a zinc phosphate (Poscal®), a polycarboxylate (Aqualox®) and glass ionomer cements with (Argion®) and without (Meron®) silver reinforcement were characterized by employing the Ames Salmonella/microsome test. The materials were eluted in dimethyl sulphoxide or physiologic saline and the aliquots were used either immediately or after an incubation period of 24 h at 37°C. Mutagenic effects of the materials were tested on Salmonella typhimurium strains TA 98, TA 100, TA 102 and TA 1535 using the standard plate incorporation assay, and in the presence or absence of S9 fraction from rat liver. Poscal® and Aqualox® elicited mutagenic effects on S. typhimurium TA 98 and TA 1535, whereas Meron® exhibited mutagenic effects on S. typhimurium TA 98. No mutagenic effects were detected for Argion®. The type of solvent, dose of the material and incubation as well as the interactions between these factors exhibited varying degrees of influences on the mutagenic activities of the cements (P<0.05 and P<0.1). We conclude that zinc phosphate, polycarboxylate, and glass ionomer cements may have possible mutagenic activities.

Keywords
Dental cements; Mutagenicity; Ames test; Salmonella typhimurium
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Mutagenic potentials of dental cements as detected by the Salmonella/microsome test
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 18, August 2004, Pages 4019–4027
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us