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Biocompatibility of sorbitol-containing polyesters. Part I: Synthesis, surface analysis and cell response in vitro ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
12924 822 2004 7 PDF Available
Title
Biocompatibility of sorbitol-containing polyesters. Part I: Synthesis, surface analysis and cell response in vitro ☆
Abstract

A series of sorbitol-containing polyesters were synthesized via a one-pot lipase-catalyzed condensation polymerization. Thin films were prepared by spin coating on silicon wafers and surfaces were analyzed by tapping mode atomic force microscopy and contact angle measurements. Surface morphologies and surface energies across the series of polyester films, including a poly(ε-caprolactone) (PCL) control were nearly indistinguishable. Biocompatibility of the sorbitol-containing polyester series was evaluated against a PCL control by measuring cell spreading and proliferation of a mouse fibroblast 3T3 cell line in vitro. Results confirmed that the sorbitol-containing polyester surfaces elicited cell behavior similar to the PCL control. These results establish the sorbitol-containing polyester series as a promising material for tissue engineering research and development.

Keywords
Functional polymer; Biocompatibility; Fibroblast; Population distribution
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Biocompatibility of sorbitol-containing polyesters. Part I: Synthesis, surface analysis and cell response in vitro ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 18, August 2004, Pages 4195–4201
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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