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Nanotopographical guidance of C6 glioma cell alignment and oriented growth

Paper ID Volume ID Publish Year Pages File Format Full-Text
12926 822 2004 9 PDF Available
Title
Nanotopographical guidance of C6 glioma cell alignment and oriented growth
Abstract

The surface properties of the extracellular matrix play vital roles in cellular behavior such as adhesion, spreading, migration, proliferation and differentiation. While cell attachment and adhesion onto surfaces are mainly mediated by surface molecular interaction, cell morphology and orientation are significantly affected by the topographical cues of the substrate. We reported here the alignment of C6 glioma cells on polystyrene (PS) substrate containing periodic nanotopography. The ridge/groove type structures (210 nm in periodicity, and 30–40 nm in depth) were generated on polystyrene surface using Nd:YAG polarized laser radiation at 266 nm. The cultured cells were shown to align strictly along the direction of the ridges/grooves. And there were distinctive features such as elongated morphology and asymmetrical cell surface extensions, revealed by confocal laser scanning microscopy (CLSM), atomic force microscopy (AFM), and scanning electron microscopy (SEM). The results indicated that ordered and continuous nanostructures on substrates can pattern cell, and guide cell alignment and oriented growth along definite directions. The possible mechanism and significance of these observations were also discussed.

Keywords
Glioma cell; Alignment; Oriented growth; Nanogroove; Polystyrene
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 18, August 2004, Pages 4215–4223
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us