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New macroporous calcium phosphate glass ceramic for guided bone regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
12928 822 2004 9 PDF Available
Title
New macroporous calcium phosphate glass ceramic for guided bone regeneration
Abstract

This work describes a method to obtain macroporous resorbable glass and glass ceramic scaffolds with controlled biodegradability for tissue engineering applications. The constructs consisted of glass and glass ceramics in the system P2O5–CaO–Na2O–TiO2 and they were prepared by foaming a slurry of glass particles by addition of a H2O2 solution, and subsequent sintering of the porous structures obtained. Different thermal treatments were applied to control the degree of devitrification of the glass. The resultant materials showed a porosity percentage between 40% and 55% with a wide variety of pores ranging from 20 to 500 μm in diameter as determined by SEM and Image Analysis. The resulting constructs were predominantly formed by a vitreous phase, although small amounts of calcium metaphosphate and pyrophosphates were detected by X-ray diffraction and Raman spectroscopy after the sintering process. The biological response was also evaluated by means of the MTT test, the material showed a non-cytotoxic effect.

Keywords
Soluble glass; Calcium phosphate; In vitro study; Scaffold; Glass–ceramic
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New macroporous calcium phosphate glass ceramic for guided bone regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 18, August 2004, Pages 4233–4241
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us