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Drug release from α,β-poly(N-2-hydroxyethyl)-dl-aspartamide-based microparticles

Paper ID Volume ID Publish Year Pages File Format Full-Text
12939 822 2004 11 PDF Available
Title
Drug release from α,β-poly(N-2-hydroxyethyl)-dl-aspartamide-based microparticles
Abstract

Spherical pH-sensitive microparticles have been prepared by reverse phase suspension polymerization technique. Starting polymer has been α,β-poly(N-2-hydroxyethyl)-dl-aspartamide (PHEA) partially derivatized with glycidylmethacrylate (GMA). PHEA-GMA copolymer (PHG) has been crosslinked in the presence of acrylic acid (AA) or methacrylic acid (MA) at various concentration. The obtained microparticles have been characterized by FT-IR spectrophotometry, particle size distribution analysis and scanning electron microscopy. In order to have information about water affinity of the prepared samples, swelling measurements have been carried out in aqueous media which simulate some biological fluids. The possibility to employ the prepared samples as pH-sensitive microparticles has been investigated by performing in vitro release studies. Experimental data have showed that the release rate from these microparticles depends on the environmental pH and the chemical structure of the drug.

Keywords
αβ-poly(N-2-hydroxyethyl)-dl-aspartamide; Glycidylmethacrylate; Radical crosslinking; pH-sensitive hydrogels; Drug release
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Drug release from α,β-poly(N-2-hydroxyethyl)-dl-aspartamide-based microparticles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 18, August 2004, Pages 4333–4343
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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Any Questions? feel free to contact us