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Luminal surface microgeometry affects platelet adhesion in small-diameter synthetic grafts

Paper ID Volume ID Publish Year Pages File Format Full-Text
12950 822 2004 9 PDF Available
Title
Luminal surface microgeometry affects platelet adhesion in small-diameter synthetic grafts
Abstract

One of the major problems when using small-diameter vascular grafts in arterial reconstruction is the development of platelet-rich thrombi as a consequence of blood contact with artificial surfaces. The degree of occlusion is certainly affected by the thrombogenicity of the internal surface that seems to play a key role in patency and long-term wound healing of grafts. In this study, the blood compatibility of Cardiothane® (CA) vascular grafts was investigated. The CA material, a blend of polyurethane and polydimethylsiloxane that has shown relatively good physical and biocompatibility properties, was manufactured into vascular grafts by the instrument named “spray-machine”. Grafts with different luminal surface porosity were produced using increasing CA concentrations by the “spray-machine” and the blood compatibility was evaluated in vitro by a circulation system in which the human blood was allowed to interact with the material in a well-controlled setting. The samples of circulating blood were collected at different times of circulation and platelet adhesion and activation were studied. Grafts with a highly porous luminal surface induced a lower adhesion and activation of platelets in vitro than the low-porosity ones. These results underlined the importance of the microgeometry of the graft luminal surface in the interaction with blood.

Keywords
Vascular grafts; Cardiothane®; Porosity; In vitro circulation; Platelet adhesion and activation; Flow cytometry
First Page Preview
Luminal surface microgeometry affects platelet adhesion in small-diameter synthetic grafts
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 18, August 2004, Pages 4447–4455
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering