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Polymeric microspheres composed of pH/temperature-sensitive polymer complex

Paper ID Volume ID Publish Year Pages File Format Full-Text
12966 823 2001 5 PDF Available
Title
Polymeric microspheres composed of pH/temperature-sensitive polymer complex
Abstract

A new pH/temperature-sensitive polymer system with transitions resulting both from polymer–water and polymer–polymer interactions has been demonstrated using the mixture of poly(N,N-dimethylamino)ethyl methacrylate (DMAEMA) and polyethyl acrylamide (EAAm). Based on the pH/temperature sensitivity of polymer mixture, the microsphere for pH/temperature-sensitive drug release have been designed and characterized. Hydrocortisone was used as a model drug. This gave the control of hydrocortisone release in an on–off manner without considerable lag time.

Keywords
Polymeric microsphere; pH/temperature-sensitive polymer mixture; On–off release of hydrocortisone
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Polymeric microspheres composed of pH/temperature-sensitive polymer complex
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 18, September 2001, Pages 2495–2499
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us