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Preparation of poly(l-lactic acid) and poly(dl-lactic-co-glycolic acid) foams by use of ice microparticulates

Paper ID Volume ID Publish Year Pages File Format Full-Text
12974 823 2001 5 PDF Available
Title
Preparation of poly(l-lactic acid) and poly(dl-lactic-co-glycolic acid) foams by use of ice microparticulates
Abstract

Biodegradable foams of poly(l-lactic acid) (PLLA) and poly(dl-lactic-co-glycolic acid) (PLGA) for tissue engineering were fabricated by a porogen-leaching technique using ice microparticulates as the porogen material. PLLA or PLGA solution in chloroform was mixed with ice microparticulates. The mixtures were frozen by being placed in molds in liquid nitrogen and freeze-dried to form the foams. Scanning electron microscopic observation of the PLLA and PLGA foams showed that evenly distributed and interconnected pore structures were formed in these foams. The porosity and surface area of the foams increased with an increase in the weight fraction of the ice microparticulates, while the median pore size remained unchanged. The pore structures of the foams could be manipulated by controlling processing variables such as the size and weight fraction of the ice microparticulates and polymer concentration.

Keywords
Poly(l-lactic acid); Poly(dl-lactic-co-glycolic acid); Biodegradable foam; Three-dimensional scaffold; Ice microparticulate; Tissue engineering
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Preparation of poly(l-lactic acid) and poly(dl-lactic-co-glycolic acid) foams by use of ice microparticulates
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 18, September 2001, Pages 2563–2567
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us