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Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions ☆

Paper ID Volume ID Publish Year Pages File Format Full-Text
12983 826 2003 10 PDF Available
Title
Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions ☆
Abstract

A series of chitosan–gelatin composite films was prepared by varying the ratio of constituents. FT-IR and X-ray analysis showed good compatibility between these two biopolymers. Differential scanning calorimetry (DSC) analysis indicated that the water take-up of chitosan film increased when blended with gelatin. Composite film exhibited a lower Young's modulus and a higher percentage of elongation-at-break compared with chitosan film, especially in wet state. All composite films were hydrophilic materials with water contact angles ranging from 55° to 65°. The results obtained from ELISA indicated the adsorption amount of fibronectin on composite films was much higher than on chitosan film. PC12 cells culture was used to evaluate the nerve cell affinity of materials. The cells cultured on the composite film with 60 wt% gelatin differentiated more rapidly and extended longer neurites than on chitosan film. The results suggest that the soft and elastic complex of chitosan and gelatin, which has better nerve cell affinity compared to chitosan, is a promising candidate biomaterial for nerve regeneration.

Keywords
Chitosan; Gelatin; Composite film; Mechanical property; Nerve cell affinity; Nerve regeneration
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Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions ☆
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 17, August 2003, Pages 2871–2880
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us