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Preparation of alginic acid layers on stainless-steel substrates for biomedical applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
12985 826 2003 6 PDF Available
Title
Preparation of alginic acid layers on stainless-steel substrates for biomedical applications
Abstract

This study is concerned with the blood compatibility of alginic acid layers immobilized on γ-aminopropyltriethoxysilane (γ-APS)-grafted stainless-steel (SUS316L). The surfaces were characterized with contact angle measurement and X-ray photoelectron spectroscopy (XPS). The blood compatibility was evaluated in terms of platelet adhesion and blood clotting time. An in vitro platelet adhesion assay indicated that only a small number of platelets adhered to substrate surfaces modified with γ-APS and subsequently with alginic acid. Moreover, alginic-acid-immobilized SUS316L substrates had little effect on the blood clotting time. This indicated that alginic-acid-immobilized SUS316L substrates do not adsorb some blood-clotting proteins or factors, or stimulate them.

Keywords
Blood compatibility; Alginic acid; γ-Aminopropyltriethoxysilane; Stainless steel; Platelet adhesion; Blood-clotting time
First Page Preview
Preparation of alginic acid layers on stainless-steel substrates for biomedical applications
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 17, August 2003, Pages 2889–2894
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering