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Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
1299 81 2009 9 PDF Available
Title
Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells
Abstract

Surface nanotopography is known to influence the interaction of human skeletal (mesenchymal) stem cells (hMSC) with a material surface. While most surface nanopatterning has been performed on polymer-based surfaces there is a need for techniques to produce well-defined topography features with tuneable sizes on relevant load-bearing implant materials such as titanium (Ti). In this study titania nanopillar structures with heights of either 15, 55 or 100 nm were produced on Ti surfaces using anodization through a porous alumina mask. The influence of the surface structure heights on hMSC adhesion, spreading, cytoskeletal formation and differentiation was examined. The 15 nm high topography features resulted in the greatest cell response with bone matrix nodule forming on the Ti surface after 21 days.

Keywords
Titanium; Nanotopography; Mesenchymal stem cell; In vitro test
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Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Acta Biomaterialia - Volume 5, Issue 5, June 2009, Pages 1433–1441
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us