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Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems

Paper ID Volume ID Publish Year Pages File Format Full-Text
12998 827 2001 6 PDF Available
Title
Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems
Abstract

The release of recombinant human bone morphogenetic protein-2 (rhBMP-2) from three room temperature polymerising methacrylate systems has been studied. These all contained poly(ethyl methacrylate) powder, but the monomer liquids comprised, respectively, tetrahydrofurfuryl methacrylate (THFM), 90/10 THFM/hydroxyethyl methacrylate (HEMA), and 70/30 THFM/HEMA. In all cases, rhBMP-2 was released, but the addition of 10% HEMA accelerated release (a nine-fold increase in diffusion coefficient); a further increase to 30% HEMA had no additional effect. For most of the release process, a diffusion process operated, although the early stages were not well defined. At the end of the 15 day period, the release, respectively, for the PEM/THFM, PEM:90/10 THFM/HEMA and PEM:70/30 THFM/HEMA systems was 596, 878 and 923 ng (i.e. up to 92% of the rhBMP-2 added).

Keywords
Water absorption; Protein release; Methacrylate polymers; rhBMP-2; Diffusion
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Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 15, 1 August 2001, Pages 2081–2086
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us