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Evaluation effects of chitosan for the extracellular matrix production by fibroblasts and the growth factors production by macrophages

Paper ID Volume ID Publish Year Pages File Format Full-Text
13003 827 2001 6 PDF Available
Title
Evaluation effects of chitosan for the extracellular matrix production by fibroblasts and the growth factors production by macrophages
Abstract

Chitosan is reported as an accelerator of wound healing. Histological findings of previous reports indicate that chitosan accelerates the reformation of connective tissue, however the details of the mechanism are not clear. In this study, firstly L929 mouse fibroblasts were cultured with chitosan and the production of extracellular matrix (ECM) was evaluated in vitro. Type I and III collagens and fibronectin were secreted by L929 with or without chitosan; however there was no significant difference in the amount of ECM between the control and the chitosan groups. Secondly, macrophages were stimulated with chitosan, and then transforming growth factor-beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) messenger ribonucleic acid (mRNA) expressions and production of their proteins were assayed in vitro. As a result, chitosan promoted the production of TGF-β1 and PDGF. These results indicate that chitosan does not directly accelerate ECM production by fibroblast and the ECM production may increase by the growth factors.

Keywords
Chitosan; Wound healing; Extracellular matrix; Growth factor
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Evaluation effects of chitosan for the extracellular matrix production by fibroblasts and the growth factors production by macrophages
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 22, Issue 15, 1 August 2001, Pages 2125–2130
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us