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The immobilization of hepatocytes on 24 nm-sized gold colloid for enhanced hepatocytes proliferation

Paper ID Volume ID Publish Year Pages File Format Full-Text
13022 828 2004 7 PDF Available
Title
The immobilization of hepatocytes on 24 nm-sized gold colloid for enhanced hepatocytes proliferation
Abstract

Bioartificial liver and hepatocyte transplantation is anticipated to supply a temporary metabolic support for candidates of liver transplantation or for patients with fulminant liver failure. An essential restriction of this form is the inability to acquire an enough amount of hepatocytes. Enhancement of the proliferation and differentiated function of hepatocytes is becoming a pursued target. Here, porcine hepatocytes were successfully immobilized on nano-sized gold colloid particles to construct a ‘‘hepatocyte/gold colloid” interface at which hepatocytes can be quickly proliferated. The properties of this resulting interface were characterized and confirmed by scanning electron microscopy and atomic force microscopy. The proliferative mechanism of hepatocytes was also discussed. The poliferated hepatocytes could be applied to the clinic based on their excellent functions for the synthesis of protein, glucose and urea as well as lower lactate dehydrogenase release.

Keywords
Hepatocyte; Gold colloid; Proliferation
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The immobilization of hepatocytes on 24 nm-sized gold colloid for enhanced hepatocytes proliferation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 17, August 2004, Pages 3445–3451
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us