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Effect of the particle size on the micro and nanostructural features of a calcium phosphate cement: a kinetic analysis

Paper ID Volume ID Publish Year Pages File Format Full-Text
13023 828 2004 10 PDF Available
Title
Effect of the particle size on the micro and nanostructural features of a calcium phosphate cement: a kinetic analysis
Abstract

The aim of this work is to investigate the possibility of controlling the final micro and nanostructural features of a calcium phosphate cement by modifying the particle size of the starting powder, and to study the effect of this parameter on the kinetics of the setting reaction. The development of calcium phosphate materials with tailored structures at the micro and nanoscale levels could allow the modulation of some specific responses in biologic phenomena such as protein adsorption and cell adhesion, which strongly depend on the nano-sized roughness of the interface.It is shown that the higher specific surface, produced by the reduction of the particle size of the powder, strongly accelerates the hydrolysis of the α-TCP into calcium-deficient hydroxyapatite. The higher degree of supersaturation attained in the solution favours the nucleation of smaller crystals. Thus, by increasing the specific surface of the starting powder in a factor of 5, the size of the precipitated crystals is strongly reduced, and the specific surface of the set cement increases by a factor of 2. The reduction of the particle size produces a substantial decrease of the setting time and accelerates the hardening of the cement without significantly affecting the final strength attained. The mechanical strength achieved by the cement cannot be univocally related to the degree of reaction, without considering the microstructural features.

Keywords
Calcium phosphate cement; Bone tissue engineering; Microstructure; Mechanical properties
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Effect of the particle size on the micro and nanostructural features of a calcium phosphate cement: a kinetic analysis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 17, August 2004, Pages 3453–3462
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us