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Hemocompatibilty of new ionic polyurethanes: influence of carboxylic group insertion modes

Paper ID Volume ID Publish Year Pages File Format Full-Text
13025 828 2004 11 PDF Available
Title
Hemocompatibilty of new ionic polyurethanes: influence of carboxylic group insertion modes
Abstract

New segmented polyurethane (PU) anionomers based on hydroxytelechelic polybutadiene (HTPB) were synthesized via two environment-friendly chemical routes. The effects of carboxylic content and ion incorporation mode on the surface properties were investigated by mean of water absorption analysis and static contact angle measurements using water, diiodomethane, formamide and ethylene glycol. Blood compatibility of the PUs was evaluated by in vitro adhesion assay using 111In-radiolabeled platelet rich plasma and 125I-fibrinogen. The morphology of platelet adhesion was also observed by scanning electron microscopy (SEM). Results were compared with a biomedical-grade PU, Pellethane®. Insertion of the carboxylic groups on the soft segments (S-α series), using thioglycolic acid (TGA), increases surface hydrophilicity, limits water uptake (5%, for an ion content of 3.6 wt%), and reduces platelet adhesion and fibrinogen adsorption on the PUs’ surfaces. In contrast, the classical insertion onto the hard segment (H-α series), using dimethylolpropionate (DMPA) as chain extender, leads to high water uptake (18%, for an ion content of 3.6 wt%) and promotes platelet and fibrinogen adhesion. SEM analyses of the non-ionic PUs exhibited surfaces with adhered platelets which underwent morphological modification. Similarly, the H-α ionic PUs show adherent and activated platelets. On the contrary, no platelet morphology changes were observed on the S-α ionic surfaces.In conclusion, insertion of carboxyl groups on the soft segments of PUs reduces their thrombogenicity.

Keywords
Polyurethane; Hemocompatibility; In vitro test; Platelet adhesion; Electron microscopy
First Page Preview
Hemocompatibilty of new ionic polyurethanes: influence of carboxylic group insertion modes
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 17, August 2004, Pages 3473–3483
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering