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Patterning protein molecules on poly(ethylene glycol) coated Si(1 1 1)

Paper ID Volume ID Publish Year Pages File Format Full-Text
13028 828 2004 7 PDF Available
Title
Patterning protein molecules on poly(ethylene glycol) coated Si(1 1 1)
Abstract

We demonstrate spatially localized immobilization of protein molecules on high-density poly(ethylene glycol) (PEG) coated Si(1 1 1). Patterns of HO- and CH3O-terminated PEG regions are formed on silicon surfaces based on soft lithography techniques and an efficient reaction between alcohol functional groups and chlorine-terminated silicon. Activation of the HO-terminated PEG brush is achieved via either partial oxidation to form aldehyde groups or via attachment of efficient leaving groups. Protein molecules are covalently immobilized to these activated regions on the PEG/Si surface.

Keywords
Surface grafting; Surface modification; Protein adsorption; Polyethylene oxide
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Patterning protein molecules on poly(ethylene glycol) coated Si(1 1 1)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 17, August 2004, Pages 3503–3509
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us