fulltext.study @t Gmail

Synthesis of a novel structural triblock copolymer of poly(γ -benzyl-l-glutamic acid)-b-poly(ethylene oxide)-b-poly(ε-caprolactone)

Paper ID Volume ID Publish Year Pages File Format Full-Text
13033 828 2004 6 PDF Available
Title
Synthesis of a novel structural triblock copolymer of poly(γ -benzyl-l-glutamic acid)-b-poly(ethylene oxide)-b-poly(ε-caprolactone)
Abstract

A novel structural triblock copolymer of poly(γ-benzyl-l-glutamic acid)-b-poly(ethylene oxide)-b-poly(ε-caprolactone) (PBLG-PEO-PCL) was synthesized by a new approach in the following three steps: (1) sequential anionic ring opening polymerization (ROP) of ethylene oxide and ε-caprolactone with an acetonitrile/potassium naphthalene initiator system to obtain a diblock copolymer CN-PEO-PCL with a cyano end-group; (2) conversion of the CN end-group into NH2 end-group by hydrogenation to obtain NH2-PEO-PCL; (3) ROP of γ-benzyl-l-glutamate-N-carboxyanhydrides (Bz-l-GluNCA) with NH2-PEO-PCL as macroinitiator to obtain the target triblock copolymer. The structures from CN-PEO precursor to the triblock copolymers were confirmed by FT-IR and 1H NMR spectroscopy, and their molecular weights were measured by gel permeation chromatography. The monomer of Bz-l-GluNCA can react almost quantitatively with the amino end-groups of NH2-PEO-PCL macroinitiator by ROP.

Keywords
Biodegradation; Poly(ε-caprolactone); Poly(ethylene oxide); Poly(γ-benzyl-l-glutamic acid); Triblock copolymer
First Page Preview
Synthesis of a novel structural triblock copolymer of poly(γ -benzyl-l-glutamic acid)-b-poly(ethylene oxide)-b-poly(ε-caprolactone)
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 17, August 2004, Pages 3553–3558
Authors
, , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us