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Development of hybrid materials based on hydroxyethylmethacrylate as supports for improving cell adhesion and proliferation

Paper ID Volume ID Publish Year Pages File Format Full-Text
13043 828 2004 9 PDF Available
Title
Development of hybrid materials based on hydroxyethylmethacrylate as supports for improving cell adhesion and proliferation
Abstract

A novel hydrogel based on 2-hydroxyethylmethacrylate and fumed silica nanoparticles is presented. The filler was mixed at increasing amount (3–40% w/w) to the organic monomer, before accomplish thermal polymerization. The hybrid composite materials obtained were characterized as far as concern the physical–chemical stability and sorption behaviour in water and water solutions. The novel hybrid hydrogels were compared to poly(hydroxyethylmethacrylate) (pHEMA) on cytocompatibility and ability to elicit cell adhesion and proliferation. These in vitro assays showed that the first ones were supporting cell growth better then pHEMA, moreover experiments on murine fibroblasts showed improved adhesion and proliferation with the increase of the nanomeric filler content. For a more physiological response, the in vitro tests should match biomaterials with cell populations typical of the implant site. Therefore, in view of future applications of these composites as scaffolds for bone engineering, in a successive step of our research we selected primary cultures of human osteoblasts (OB) as the most appropriate models to study the in vitro performance of these materials. The preliminary results obtained confirmed the remarkable improvement of OB adhesion properties of the new hybrids with respect to pure pHEMA.

Keywords
Nanostructured materials; Poly(hydroxyethylmethacrylate); Biocompatibility
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Development of hybrid materials based on hydroxyethylmethacrylate as supports for improving cell adhesion and proliferation
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 17, August 2004, Pages 3645–3653
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us