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Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices

Paper ID Volume ID Publish Year Pages File Format Full-Text
13052 828 2004 8 PDF Available
Title
Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices
Abstract

Novel polyampholyte hydrogels based on carboxymethyl chitosans (CMC) of various degree of deacetylation (DD) and substitution (DS) were prepared by crosslinking with glutaraldehyde. The hydrogel showed typical amphoteric character responding to pH of the external medium. At the isoelectric point (IEP), the hydrogel shrunk most, when the pH deviated from IEP, the swelling degree (Ds) increased. With increasing DD or DS value, the hydrogel changed from polyampholyte into polycations or polyanions, respectively. Osmotic forces and intermolecular interactions among CMC chains regulate the swelling behavior of CMC gel. The carboxymethyl chitin hydrogels were loaded with bovine blood proteins (BSA), and their release studies were performed in both the simulated gastric and intestinal pH conditions. The release was much quicker in pH 7.4 buffer than pH 1.2 solution; the release followed Fickian diffusion in the first 4 h and then steadily increased with the dissolution of the hydrogels.

Keywords
Carboxymethyl chitosan; Polyampholyte hydrogel; pH sensitivity; Drug delivery; BSA
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Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 17, August 2004, Pages 3725–3732
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us