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Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release

Paper ID Volume ID Publish Year Pages File Format Full-Text
13057 828 2004 10 PDF Available
Title
Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release
Abstract

The nitric oxide (NO) donor S-nitrosoglutathione (GSNO) was incorporated in solid polymeric films of poly(vinyl alcohol) (PVA), poly(vinyl pyrrolidone) (PVP) and blended PVA/PVP. These matrices were found to provide a great stabilization effect on the thermal decomposition of GSNO, leading to 8–16-fold reduction in the first-order rate constants of NO release, compared to aqueous GSNO solutions. PVA/PVP-GSNO released 90% of the NO supply, over a time period of 24 h at 37°C. Differential scanning calorimetry has confirmed the miscibility between the two polymeric components. Stress–strain analysis has shown an improvement of the mechanical property of PVA films in the PVA/PVP blend, which leads to an increase of 25% in the stress at break. Scanning electron microscopy has shown that the PVA/PVP-GSNO blend leads to a smooth coating of metallic surfaces. These properties, allied to the already known good biocompatibility of PVA and PVP, makes GSNO-containing PVA and PVA/PVP blend films good candidates for the local and controlled release of NO in target areas.

Keywords
S-nitrosoglutathione; Nitric oxide; Poly(vinyl alcohol); Poly(vinyl pyrrolidone); NO release
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Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 25, Issue 17, August 2004, Pages 3773–3782
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us