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Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
13075 829 2002 11 PDF Available
Title
Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering
Abstract

In the year 2000 a new rapid prototyping (RP) technology was developed at the Freiburg Materials Research Center to meet the demands for desktop fabrication of scaffolds useful in tissue engineering. A key feature of this RP technology is the three-dimensional (3D) dispensing of liquids and pastes in liquid media. In contrast to conventional RP systems, mainly focused on melt processing, the 3D dispensing RP process (3D plotting) can apply a much larger variety of synthetic as well as natural materials, including aqueous solutions and pastes, to fabricate scaffolds for application in tissue engineering. For the first time, hydrogel scaffolds with a designed external shape and a well-defined internal pore structure were prepared by this RP process. Surface coating and pore formation were achieved to facilitate cell adhesion and cell growth. The versatile application potential of new hydrogel scaffolds was demonstrated in cell culture.

Keywords
Rapid prototyping; Tissue engineering; Hydrogel; 3D dispensing; 3D plotting
First Page Preview
Rapid prototyping of scaffolds derived from thermoreversible hydrogels and tailored for applications in tissue engineering
Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 23, December 2002, Pages 4437–4447
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering