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Variation of nanomechanical properties of bone by gene mutation in the zebrafish

Paper ID Volume ID Publish Year Pages File Format Full-Text
13089 829 2002 7 PDF Available
Title
Variation of nanomechanical properties of bone by gene mutation in the zebrafish
Abstract

Significant variations of nanomechanical properties and fracture morphology between gene-mutated liliputdtc232(lil/lil) zebrafish skeletal bone and wild-type bone have been observed. Nanoindentation measurement disclosed that lil/lil bone has 36% lower nanohardness and 32% lower elastic modulus. The standard deviations of hardness and elastic modulus of lil/lil bone were both much higher than those of wild-type bone. SEM morphology of fracture surfaces further revealed that in bones after gene mutation, formative microcracks make the performance reduction and the increasing of brittleness. What is more, the plywood-like structure of the normal bone does not exist in the lil/lil bone.

Keywords
Gene mutation; Nanoindentation; Bone; Zebrafish
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Variation of nanomechanical properties of bone by gene mutation in the zebrafish
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 23, Issue 23, December 2002, Pages 4557–4563
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us