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Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid

Paper ID Volume ID Publish Year Pages File Format Full-Text
13107 831 2003 8 PDF Available
Title
Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid
Abstract

Carboxymethylated chitin, gellan gum, and curdlan gels were soaked in a simulated body fluid (SBF) having ion concentrations nearly equal to those of human blood plasma. Some of the gels had been soaked in a saturated Ca(OH)2 solution, while others had not. The carboxymethylated chitin and gellan gum gels have carboxyl groups, while the curdlan gel has hydroxyl groups. None of the gels formed apatite on their surfaces in the SBF when they had not been subjected to the Ca(OH)2 treatment, whereas the carboxymethylated chitin and gellan gum gels formed apatite on their surfaces when they had been subjected to the Ca(OH)2 treatment. The curdlan gel did not form an apatite deposit even after the Ca(OH)2 treatment. Apatite formation on the carboxymethylated chitin and gellan gum gels was attributed to the catalytic effect of their carboxyl groups for apatite nucleation, and acceleration of apatite nucleation from released Ca2+ ions. This result provides a guiding principle for obtaining apatite-organic polymer fiber composites. This composite is expected to have an analogous structure to that of natural bone.

Keywords
Carboxyl group; Polymer; Apatite; Composite; Simulated body fluid; Biomimetic method
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Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid
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Publisher
Database: Elsevier - ScienceDirect
Journal: Biomaterials - Volume 24, Issue 14, June 2003, Pages 2477–2484
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
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Full-text PDF Download
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